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Contains residues characteristic of the PR, GR, and MR, but not AR, indicating that it bound C21 steroids rather than C19 androgens like testosterone or dihydrotesterone. However, they note that it can take up to 4 weeks to start to notice results. Functions mentioned above, the major roles of plasma binding proteins seem to be (a) to act as a buffer or reservoir for active hormones (because of the non-covalent nature of the binding, protein-bound steroids are released into the plasma in free form as soon as the free concentration drops according to the law of mass action) and (b) to protect the hormone from peripheral metabolism (notably by liver enzymes) and increase the half-life of biologically active forms.

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